No prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence

Aaron R. Folsom, Paul S. de Vries, Mary Cushman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Previous studies are inconsistent about whether chronic coronary artery disease or generalized atherosclerosis is a causal risk factor for venous thromboembolism. No study seems to have taken a genomic approach to this question. Objective: To test in a prospective study whether a polygenic risk score for coronary artery disease is associated with risk of venous thromboembolism. Participants/Methods: Within the Atherosclerosis Risk in Communities Study cohort, we computed a previously validated polygenic risk score for coronary artery disease among 9144 White participants at baseline in 1987–1989. We followed the participants through 2015 for incident hospitalized venous thromboembolism events, validated by physician review. We used Cox proportional hazards regression to associate quintiles of the polygenic risk score to venous thromboembolism incidence rates. Results: Over the median of 26 years of follow-up, 476 participants had a venous thromboembolism event. There was no apparent association between the coronary artery disease polygenic risk score and incident venous thromboembolism, with age, sex, body mass index adjusted hazard ratios across quintiles being 1 (reference), 0.87 (0.65, 1.15), 1.08 (0.82, 1.42), 0.96 (0.72, 1.27), and 1.03 (0.78, 1.37). Conclusions: A genetic disposition to coronary artery disease did not confer an increased risk of venous thromboembolism in this prospective study.

Original languageEnglish (US)
Number of pages4
JournalJournal of Thrombosis and Haemostasis
Volume19
Issue number11
Early online dateAug 19 2021
DOIs
StateE-pub ahead of print - Aug 19 2021

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services (contract numbers HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, and HHSN268201700005I), R01HL087641, R01HL059367, and R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. Infrastructure was partly supported by grant number UL1RR025005, a component of the National Institutes of Health and NIH Roadmap for Medical Research. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. The authors thank the staff and participants of the ARIC study for their important contributions.

Publisher Copyright:
© 2021 International Society on Thrombosis and Haemostasis

Keywords

  • coronary artery disease
  • polygenetic risk score
  • prospective study
  • pulmonary embolism
  • venous thrombosis

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