For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preserve some endogenous islet function in the majority of recipients, which mediates protection against brittle diabetes. Most maintain reasonably good glycemic control, while 30%-40% successfully discontinue insulin therapy. With islet autotransplants reaching a wider clinical audience, refinements in islet isolation techniques and strategies to protect islet grafts post-transplant may further improve the success of this procedure.
Bibliographical noteFunding Information:
Acknowledgments M.B. is supported by a career development award from the National Institute of Diabetes, Digestive, and Kidney Diseases (1K23DK084315-01A1). The authors thank Dr David Radosevich for his contributions to the data analysis.
- Alpha cell
- Beta cell
- Chronic Pancreatitis
- Diabetes mellitus
- Islet transplant