No evidence for colonization of oral bacteria in the distal gut in healthy adults

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26 Scopus citations

Abstract

The microbial communities in the mouth and colon are anatomically connected via the saliva. However, the extent to which oral microbes reach and successfully colonize the distal gut has been debated. To resolve this long-standing controversy, we used exact amplicon sequence variants generated from concurrently collected saliva/stool microbiota in 66 healthy adults from two countries to show that, with one exception (Dialister invisus), the two niches are completely distinct. Thus, there is no evidence for colonization of oral bacteria in the distal gut. This defines the healthy state to which pathological states could be compared. Finding the same bacteria in the mouth and stool may warrant clinical investigation for an underlying pathology.

Original languageEnglish (US)
Article numbere2114152118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number42
DOIs
StatePublished - Oct 19 2021

Bibliographical note

Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.

Keywords

  • Dialister invisus
  • Oral microbiota
  • gut microbiota

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