The microbial communities in the mouth and colon are anatomically connected via the saliva. However, the extent to which oral microbes reach and successfully colonize the distal gut has been debated. To resolve this long-standing controversy, we used exact amplicon sequence variants generated from concurrently collected saliva/stool microbiota in 66 healthy adults from two countries to show that, with one exception (Dialister invisus), the two niches are completely distinct. Thus, there is no evidence for colonization of oral bacteria in the distal gut. This defines the healthy state to which pathological states could be compared. Finding the same bacteria in the mouth and stool may warrant clinical investigation for an underlying pathology.
|Original language||English (US)|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Oct 19 2021|
Bibliographical noteFunding Information:
ACKNOWLEDGMENTS. Sequence data were analyzed using the resources of the Minnesota Supercomputing Institute. This work was supported by NIH’s National Center for Advancing Translational Sciences Grant KL2TR002492. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH’s National Center for Advancing Translational Sciences.
© 2021 National Academy of Sciences. All rights reserved.
- Dialister invisus
- Oral microbiota
- gut microbiota