No-D NMR (No-Deuterium Proton NMR) spectroscopy: A simple yet powerful method for analyzing reaction and reagent solutions

Thomas R. Hoye, Brian M. Eklov, Troy D. Ryba, Mikhail Voloshin, Letitia J. Yao

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

(Equation presented) The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.

Original languageEnglish (US)
Pages (from-to)953-956
Number of pages4
JournalOrganic Letters
Volume6
Issue number6
DOIs
StatePublished - Mar 18 2004

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