No-D NMR (No-Deuterium Proton NMR) spectroscopy: A simple yet powerful method for analyzing reaction and reagent solutions

Thomas R. Hoye; Brian M. Eklov; Troy D. Ryba; Mikhail Voloshin; Letitia J. Yao

doi:10.1021/ol049979+

No-D NMR (No-Deuterium Proton NMR) spectroscopy: A simple yet powerful method for analyzing reaction and reagent solutions

Thomas R. Hoye, Brian M. Eklov, Troy D. Ryba, Mikhail Voloshin, Letitia J. Yao

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Abstract

(Equation presented) The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.

Original language	English (US)
Pages (from-to)	953-956
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/ol049979+
State	Published - Mar 18 2004

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abstract = "(Equation presented) The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.",

author = "Hoye, {Thomas R.} and Eklov, {Brian M.} and Ryba, {Troy D.} and Mikhail Voloshin and Yao, {Letitia J.}",

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T1 - No-D NMR (No-Deuterium Proton NMR) spectroscopy

T2 - A simple yet powerful method for analyzing reaction and reagent solutions

AU - Hoye, Thomas R.

AU - Eklov, Brian M.

AU - Ryba, Troy D.

AU - Voloshin, Mikhail

AU - Yao, Letitia J.

PY - 2004/3/18

Y1 - 2004/3/18

N2 - (Equation presented) The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.

AB - (Equation presented) The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.

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No-D NMR (No-Deuterium Proton NMR) spectroscopy: A simple yet powerful method for analyzing reaction and reagent solutions

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