No baseline for blood pressure in ordinary life: Another case of transient chronome alterations

Tina Sarabandi, Jay N Cohn, Germaine G Cornelissen-Guillaume, Franz Halberg, George Katinas, James Holte, Othild Schwartzkopff, Kuniaki Otsuka

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Half-hourly systolic (S) and diastolic (D) blood pressure (BP) and heart rate (HR) monitoring with gaps demonstrates transient elevations of unknown origin of the chronome (time structure)-adjusted mean, the MESOR, M, of BP, and of the circadian double amplitude of BP of TS, a clinically healthy-appearing engineering student who was 27 years of age at the start of the study. An assessment of large and small arterial vessel elasticity was in keeping with no detection of functional or structural alteration in her vasculature. The recovery of normality in BP endpoints at the time of this report is speculatively associated with a weight loss of 40 pounds and the formation of a friendship by correspondence. Whatever the underlying mechanisms of a long series of abnormal records may be, a 'baseline' can include weeklong spans of abnormality and is best replaced by comparisons with chronomic reference values.

Original languageEnglish (US)
Pages (from-to)S107-S110
JournalBiomedicine and Pharmacotherapy
Issue numberSUPPL. 1
StatePublished - Oct 2004

Bibliographical note

Funding Information:
This study was supported by an NIH grant (GM-13981) (to FH), and by a grant from the University of Minnesota Supercomputing Institute (to GC, FH).


  • Arterial compliance
  • Blood pressure
  • CHAT
  • Circadian hyper-amplitude-tension
  • Debunking baseline
  • Emotion
  • Heart rate
  • MESOR-hypertension
  • Reference values


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