No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study

Bharat Thyagarajan, Kristin E. Anderson, Aaron R. Folsom, David R. Jacobs, Charles F. Lynch, Archana Bargaje, Waseem Khaliq, Myron D. Gross

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms-PCR-RFLP, PCR-INVADER, or Sequenom. Results: None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95% CI: 0.78-1.88); Arg399Gln (OR = 1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR = 1.04, 95% CI: 0.76-1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.

Original languageEnglish (US)
Pages (from-to)313-321
Number of pages9
JournalCancer Detection and Prevention
Volume30
Issue number4
DOIs
StatePublished - Sep 22 2006

Keywords

  • Arg399Gln
  • BMI
  • Base excision repair
  • DNA repair
  • Double strand DNA repair
  • Genotype
  • INVADER assay
  • IWHS
  • Nested case control study
  • Paraffin embedded tissue
  • Polymorphisms
  • Postmenopausal breast cancer
  • Risk factors
  • Statistical analysis

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