NMR Studies of Large Proteins

Yajun Jiang, Charalampos Kalodimos

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Recent breakthroughs in isotope-labeling and pulse sequence techniques have enabled the NMR characterization of large protein systems with molecular masses of hundreds of kilodaltons. NMR studies of a great variety of large proteins have provided unique insights into the binding, dynamic, and allosteric mechanisms. Here we present a brief summary of these developments by highlighting few cases that exemplify the uniqueness of NMR in providing atomic resolution information into key dynamic processes and structures of protein complexes with high degree of flexibility.

Original languageEnglish (US)
Pages (from-to)2667-2676
Number of pages10
JournalJournal of Molecular Biology
Issue number17
StatePublished - Aug 18 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd


  • NMR spectroscopy
  • large proteins
  • protein complexes


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