NMR reveals novel mechanisms of protein activity regulation

Charalampos G. Kalodimos

doi:10.1002/pro.614

NMR reveals novel mechanisms of protein activity regulation

Charalampos G. Kalodimos

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an integrated insight into both the structure and intrinsic dynamics of biomolecules. In addition, NMR can provide siteresolved information about the conformation entropy of binding, as well as about energetically excited conformational states. Recent advances have enabled the application of NMR for the characterization of supramolecular systems. A summary of mechanisms underpinning protein activity regulation revealed by the application of NMR spectroscopy in a number of biological systems studied in the lab is provided.

Original language	English (US)
Pages (from-to)	773-782
Number of pages	10
Journal	Protein Science
Volume	20
Issue number	5
DOIs	https://doi.org/10.1002/pro.614
State	Published - May 2011
Externally published	Yes

Keywords

Allosteric interactions
Autoinhibition
NMR
Protein function
Protein regulation

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abstract = "NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an integrated insight into both the structure and intrinsic dynamics of biomolecules. In addition, NMR can provide siteresolved information about the conformation entropy of binding, as well as about energetically excited conformational states. Recent advances have enabled the application of NMR for the characterization of supramolecular systems. A summary of mechanisms underpinning protein activity regulation revealed by the application of NMR spectroscopy in a number of biological systems studied in the lab is provided.",

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AB - NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an integrated insight into both the structure and intrinsic dynamics of biomolecules. In addition, NMR can provide siteresolved information about the conformation entropy of binding, as well as about energetically excited conformational states. Recent advances have enabled the application of NMR for the characterization of supramolecular systems. A summary of mechanisms underpinning protein activity regulation revealed by the application of NMR spectroscopy in a number of biological systems studied in the lab is provided.

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KW - Autoinhibition

KW - NMR

KW - Protein function

KW - Protein regulation

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NMR reveals novel mechanisms of protein activity regulation

Abstract

Keywords

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