NMR chemical shift imaging in three dimensions

T. R. Brown, B. M. Kincaid, K. Ugurbil

Research output: Contribution to journalArticlepeer-review

975 Scopus citations


A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The method uses a sequence of pulsed field gradients to measure the Fourier transform of the desired distribution on a rectangular grid in (k,t) space. Simple Fourier inversion then recovers the original distribution. An estimated signal/noise ratio of 20 in 10 min is obtained for an 'image' of the distribution of a 10 mM phosphorylated metabolite in the human head at a field of 20 kG with 2-cm resolution.

Original languageEnglish (US)
Pages (from-to)3523-3526
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number11 I
StatePublished - 1982


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