Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and Nutrition Examination Survey

Charles H. Weir; Karin B. Yeatts; Jeremy A. Sarnat; William Vizuete; Päivi M. Salo; Renee Jaramillo; Richard D. Cohn; Haitao Chu; Darryl C. Zeldin; Stephanie J. London

doi:10.1016/j.rmed.2013.08.010

Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and Nutrition Examination Survey

Charles H. Weir
, Karin B. Yeatts
, Jeremy A. Sarnat
, William Vizuete
, Päivi M. Salo
, Renee Jaramillo
, Richard D. Cohn
, Haitao Chu
, Darryl C. Zeldin
, Stephanie J. London

Biostatistics

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background Allergic sensitization is a risk factor for asthma and allergic diseases. The relationship between ambient air pollution and allergic sensitization is unclear. Objective To investigate the relationship between ambient air pollution and allergic sensitization in a nationally representative sample of the US population. Methods We linked annual average concentrations of nitrogen dioxide (NO₂), particulate matter ≤10 μm (PM ₁₀), particulate matter ≤2.5 μm (PM_2.5), and summer concentrations of ozone (O₃), to allergen-specific immunoglobulin E (IgE) data for participants in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). In addition to the monitor-based air pollution estimates, we used the Community Multiscale Air Quality (CMAQ) model to increase the representation of rural participants in our sample. Logistic regression with population-based sampling weights was used to calculate adjusted prevalence odds ratios per 10 ppb increase in O₃ and NO₂, per 10 μg/m³ increase in PM₁₀, and per 5 μg/m³ increase in PM_2.5 adjusting for race, gender, age, socioeconomic status, smoking, and urban/rural status. Results Using CMAQ data, increased levels of NO₂ were associated with positive IgE to any (OR 1.15, 95% CI 1.04, 1.27), inhalant (OR 1.17, 95% CI 1.02, 1.33), and indoor (OR 1.16, 95% CI 1.03, 1.31) allergens. Higher PM_2.5 levels were associated with positivity to indoor allergen-specific IgE (OR 1.24, 95% CI 1.13, 1.36). Effect estimates were similar using monitored data. Conclusions Increased ambient NO₂ was consistently associated with increased prevalence of allergic sensitization.

Original language	English (US)
Pages (from-to)	1763-1772
Number of pages	10
Journal	Respiratory Medicine
Volume	107
Issue number	11
DOIs	https://doi.org/10.1016/j.rmed.2013.08.010
State	Published - Nov 2013

Bibliographical note

Funding Information:
This research was supported in part by Division of Health Studies Agency for Toxic Substances and Disease Registry, and the Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, DHHS. The findings and conclusions in this article are those of the authors and do not represent the views of the National Center for Environmental Health/Agency for Toxic Substances and Disease Registry or National Institute of Environmental Health Sciences.

Keywords

Air pollution
Allergic
Epidemiology
IgE
NHANES
Sensitization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rmed.2013.08.010

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@article{3065ae1e40ae4dd8a260e9c9cd0840aa,

title = "Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and Nutrition Examination Survey",

abstract = "Background Allergic sensitization is a risk factor for asthma and allergic diseases. The relationship between ambient air pollution and allergic sensitization is unclear. Objective To investigate the relationship between ambient air pollution and allergic sensitization in a nationally representative sample of the US population. Methods We linked annual average concentrations of nitrogen dioxide (NO2), particulate matter ≤10 μm (PM 10), particulate matter ≤2.5 μm (PM2.5), and summer concentrations of ozone (O3), to allergen-specific immunoglobulin E (IgE) data for participants in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). In addition to the monitor-based air pollution estimates, we used the Community Multiscale Air Quality (CMAQ) model to increase the representation of rural participants in our sample. Logistic regression with population-based sampling weights was used to calculate adjusted prevalence odds ratios per 10 ppb increase in O3 and NO2, per 10 μg/m3 increase in PM10, and per 5 μg/m3 increase in PM2.5 adjusting for race, gender, age, socioeconomic status, smoking, and urban/rural status. Results Using CMAQ data, increased levels of NO2 were associated with positive IgE to any (OR 1.15, 95\% CI 1.04, 1.27), inhalant (OR 1.17, 95\% CI 1.02, 1.33), and indoor (OR 1.16, 95\% CI 1.03, 1.31) allergens. Higher PM2.5 levels were associated with positivity to indoor allergen-specific IgE (OR 1.24, 95\% CI 1.13, 1.36). Effect estimates were similar using monitored data. Conclusions Increased ambient NO2 was consistently associated with increased prevalence of allergic sensitization.",

keywords = "Air pollution, Allergic, Epidemiology, IgE, NHANES, Sensitization",

author = "Weir, \{Charles H.\} and Yeatts, \{Karin B.\} and Sarnat, \{Jeremy A.\} and William Vizuete and Salo, \{P{\"a}ivi M.\} and Renee Jaramillo and Cohn, \{Richard D.\} and Haitao Chu and Zeldin, \{Darryl C.\} and London, \{Stephanie J.\}",

note = "Funding Information: This research was supported in part by Division of Health Studies Agency for Toxic Substances and Disease Registry, and the Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, DHHS. The findings and conclusions in this article are those of the authors and do not represent the views of the National Center for Environmental Health/Agency for Toxic Substances and Disease Registry or National Institute of Environmental Health Sciences. ",

year = "2013",

month = nov,

doi = "10.1016/j.rmed.2013.08.010",

language = "English (US)",

volume = "107",

pages = "1763--1772",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

number = "11",

}

TY - JOUR

T1 - Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and Nutrition Examination Survey

AU - Weir, Charles H.

AU - Yeatts, Karin B.

AU - Sarnat, Jeremy A.

AU - Vizuete, William

AU - Salo, Päivi M.

AU - Jaramillo, Renee

AU - Cohn, Richard D.

AU - Chu, Haitao

AU - Zeldin, Darryl C.

AU - London, Stephanie J.

N1 - Funding Information: This research was supported in part by Division of Health Studies Agency for Toxic Substances and Disease Registry, and the Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, DHHS. The findings and conclusions in this article are those of the authors and do not represent the views of the National Center for Environmental Health/Agency for Toxic Substances and Disease Registry or National Institute of Environmental Health Sciences.

PY - 2013/11

Y1 - 2013/11

N2 - Background Allergic sensitization is a risk factor for asthma and allergic diseases. The relationship between ambient air pollution and allergic sensitization is unclear. Objective To investigate the relationship between ambient air pollution and allergic sensitization in a nationally representative sample of the US population. Methods We linked annual average concentrations of nitrogen dioxide (NO2), particulate matter ≤10 μm (PM 10), particulate matter ≤2.5 μm (PM2.5), and summer concentrations of ozone (O3), to allergen-specific immunoglobulin E (IgE) data for participants in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). In addition to the monitor-based air pollution estimates, we used the Community Multiscale Air Quality (CMAQ) model to increase the representation of rural participants in our sample. Logistic regression with population-based sampling weights was used to calculate adjusted prevalence odds ratios per 10 ppb increase in O3 and NO2, per 10 μg/m3 increase in PM10, and per 5 μg/m3 increase in PM2.5 adjusting for race, gender, age, socioeconomic status, smoking, and urban/rural status. Results Using CMAQ data, increased levels of NO2 were associated with positive IgE to any (OR 1.15, 95% CI 1.04, 1.27), inhalant (OR 1.17, 95% CI 1.02, 1.33), and indoor (OR 1.16, 95% CI 1.03, 1.31) allergens. Higher PM2.5 levels were associated with positivity to indoor allergen-specific IgE (OR 1.24, 95% CI 1.13, 1.36). Effect estimates were similar using monitored data. Conclusions Increased ambient NO2 was consistently associated with increased prevalence of allergic sensitization.

AB - Background Allergic sensitization is a risk factor for asthma and allergic diseases. The relationship between ambient air pollution and allergic sensitization is unclear. Objective To investigate the relationship between ambient air pollution and allergic sensitization in a nationally representative sample of the US population. Methods We linked annual average concentrations of nitrogen dioxide (NO2), particulate matter ≤10 μm (PM 10), particulate matter ≤2.5 μm (PM2.5), and summer concentrations of ozone (O3), to allergen-specific immunoglobulin E (IgE) data for participants in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). In addition to the monitor-based air pollution estimates, we used the Community Multiscale Air Quality (CMAQ) model to increase the representation of rural participants in our sample. Logistic regression with population-based sampling weights was used to calculate adjusted prevalence odds ratios per 10 ppb increase in O3 and NO2, per 10 μg/m3 increase in PM10, and per 5 μg/m3 increase in PM2.5 adjusting for race, gender, age, socioeconomic status, smoking, and urban/rural status. Results Using CMAQ data, increased levels of NO2 were associated with positive IgE to any (OR 1.15, 95% CI 1.04, 1.27), inhalant (OR 1.17, 95% CI 1.02, 1.33), and indoor (OR 1.16, 95% CI 1.03, 1.31) allergens. Higher PM2.5 levels were associated with positivity to indoor allergen-specific IgE (OR 1.24, 95% CI 1.13, 1.36). Effect estimates were similar using monitored data. Conclusions Increased ambient NO2 was consistently associated with increased prevalence of allergic sensitization.

KW - Air pollution

KW - Allergic

KW - Epidemiology

KW - IgE

KW - NHANES

KW - Sensitization

UR - https://www.scopus.com/pages/publications/84887066532

UR - https://www.scopus.com/pages/publications/84887066532#tab=citedBy

U2 - 10.1016/j.rmed.2013.08.010

DO - 10.1016/j.rmed.2013.08.010

M3 - Article

C2 - 24045117

AN - SCOPUS:84887066532

SN - 0954-6111

VL - 107

SP - 1763

EP - 1772

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 11

ER -

Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and Nutrition Examination Survey

Abstract

Bibliographical note

Keywords

UN SDGs

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