Nisoldipine cardioplegia in the isolated rabbit heart

U. Acikel, E. Hazan, N. Sariosmanoglu, H. Catalyurek, E. Silistreli, G. Guner, N. Saydam, Y. Tuncok, H. Guven, O. Karabay, O. Oto

Research output: Contribution to journalArticlepeer-review


Background: The metabolic and hemodynamic effects of nisoldipine supplementation in cardioplegia after ischemic injury were investigated in 13 isolated rabbit hearts. Group 1 consisted of 6 hearts, which received St. Thomas II cardioplegic solution. In group 2, nisoldipine was added to the cardioplegic solution at a concentration of 0.1 mg/kg in 7 hearts. Methods: The explanted hearts were suspended from Langendorff apparatus and were perfused with Krebs-Henseleit solution. Left ventricular pressure, heart rate, malondialdehyde, glutathione peroxidase, glutathione reductase, reduced glutathione, oxidized glutathione, creatine kinase MB, (CK-MB), aspartate transaminase, and lactate dehydrogenase (LDH) were measured before and after 60 minutes of ischemia. Peak generated pressure after ischemia was significantly higher in group 2 versus group 1 while end-diastolic pressure was significantly lower in group 2 after ischemic arrest (P < .05). Results: Malondialdehyde levels were lower in group 2 (P < .05). Glutathione peroxidase and glutathione reductase levels were significantly higher in group 2 (P < .05). The only enzymatic significant difference was observed between the preischemic and postischemic levels of aspartate transaminase in group 2 (P < .05). Conclusions: These findings show beneficial effects of nisoldipine cardioplegia, although its use as a cardioplegic additive is not yet possible. We believe, however, the effects of oral nisoldipine before cardiac surgery can be studied in a clinical setting.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Issue number4
StatePublished - 1997
Externally publishedYes


  • Cardioplegia
  • Isolated rabbit heart
  • Myocardial protection
  • Nisoldipin


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