Nicotine-induced release of elastase and eicosanoids by human neutrophils

W. Kim Seow, Y. H. Thong, R. D. Nelson, G. D. Macfarlane, Mark C Herzberg

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

We examined the direct effects of nicotine on a variety of neutrophil functions at concentrations achievable in lung and oral tissues from cigarette smoking. The results show dose-dependent suppression of chemotaxis and phagocytosis, and enhancement of degranulation and eicosanoid generation, but not superoxide production. Cell viability was not affected by the concentrations of nicotine used in these experiments, as shown by trypan blue dye exclusion and MTT assays. These results implicate nicotine as the ingredient in cigarette smoke responsible for inflammatory damage to lungs and oral tissues observed in cigarette smokers.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalInflammation
Volume18
Issue number2
DOIs
StatePublished - Apr 1994

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