Nicotine as a factor in stress responsiveness among detoxified alcoholics

Rebecca Gilbertson, Reginald F. Frye, Sara Jo Nixon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Aims: The effect of transdermal nicotine on stress reactivity was investigated in currently smoking, detoxified, substance-dependent individuals (65% alcohol dependent, n = 51; 31 male) following a psychosocial stressor. Methods: Using a randomized, double-blind, placebo-controlled design, subjects were assigned to receive either active transdermal nicotine (low or high dose) or placebo. Six hours following nicotine administration, subjects performed a laboratory psychosocial stressor consisting of two 4-min public-speaking sessions. Results: Consistent with prior reports, substance-dependent individuals displayed a blunted stress response. However, a review of the cortisol distribution data encouraged additional analyses. Notably, a significant minority of the substance-dependent individuals (33%) demonstrated elevated poststress cortisol levels. This group of responders was more likely to be alcohol dependent and to have received the high dose of nicotine [χ2(2)=32, P<0.0001], [χ2(2)=18.66, P < 0.0001]. Differences in salivary cortisol responses between responders and nonresponders could not be accounted for by the length of sobriety, nicotine withdrawal levels, anxiety or depressive symptomatology at the time of the psychosocial stressor. Conclusion: These results suggest that nicotine administration may support a normalization of the salivary cortisol response following psychosocial stress in subgroups of substance-dependent individuals, particularly those who are alcohol dependent. Given the association between blunted cortisol levels and relapse, and the complex actions of nicotine at central and peripheral sites, these findings support the systematic study of factors including nicotine, which may influence stress reactivity and the recovery process in alcohol-dependent individuals.

Original languageEnglish (US)
Article numberagq070
Pages (from-to)39-51
Number of pages13
JournalAlcohol and Alcoholism
Issue number1
StatePublished - Jan 2011

Bibliographical note

Funding Information:
Funding — Funding for this study was provided by the National Institutes of Health NIDA and the McKnight Brain Institute at the University of Florida. These funding bodies had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or the decision to submit the paper for publication. Support was provided in part by grants R01 DA-13677 (Nixon) and a dissertation award from the McKnight Brain Institute (Gilbertson).


Dive into the research topics of 'Nicotine as a factor in stress responsiveness among detoxified alcoholics'. Together they form a unique fingerprint.

Cite this