Nickel enrichment of next-generation NMC nanomaterials alters material stability, causing unexpected dissolution behavior and observed toxicity to: S. oneidensis MR-1 and D. magna

Joseph T. Buchman, Evan A. Bennett, Chenyu Wang, Ali Abbaspour Tamijani, Joseph W. Bennett, Blake G. Hudson, Curtis M. Green, Peter L. Clement, Bo Zhi, Austin H. Henke, Elizabeth D. Laudadio, Sara E. Mason, Robert J. Hamers, Rebecca D. Klaper, Christy L. Haynes

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Lithium intercalation compounds, such as the complex metal oxide, lithium nickel manganese cobalt oxide (LiNixMnyCo1-x-yO2, herein referred to as NMC), have demonstrated their utility as energy storage materials. In response to recent concerns about the global supply of cobalt, industrially synthesized NMCs are shifting toward using NMC compositions with enriched nickel content. However, nickel is one of the more toxic components of NMC materials, meriting investigation of the toxicity of these materials on environmentally relevant organisms. Herein, the toxicity of both nanoscale and microscale Ni-enriched NMCs to the bacterium, Shewanella oneidensis MR-1, and the zooplankton, Daphnia magna, was assessed. Unexpectedly, for the bacteria, all NMC materials exhibited similar toxicity when used at equal surface area-based doses, despite the different nickel content in each. Material dissolution to toxic species, namely nickel and cobalt ions, was therefore modelled using a combined density functional theory and thermodynamics approach, which showed an increase in material stability due to the Ni-enriched material containing nickel with an oxidation state >2. The increased stability of this material means that similar dissolution is expected between Ni-enriched NMC and equistoichiometric NMC, which is what was found in experiments. For S. oneidensis, the toxicity of the released ions recapitulated toxicity of NMC nanoparticles. For D. magna, nickel enrichment increased the observed toxicity of NMC, but this toxicity was not due to ion release. Association of the NMC was observed with both S. oneidensis and D. magna. This work demonstrates that for organisms where the major mode of toxicity is based on ion release, including more nickel in NMC does not impact toxicity due to increased particle stability; however, for organisms where the core composition dictates the toxicity, including more nickel in the redesign strategy may lead to greater toxicity due to nanoparticle-specific impacts on the organism.

Original languageEnglish (US)
Pages (from-to)571-587
Number of pages17
JournalEnvironmental Science: Nano
Issue number2
StatePublished - Feb 2020

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation under the Center for Sustainable Nanotechnology, CHE-1503408. The CSN is part of the Centers for Chemical Innovation Program. J. T. B. was supported by a National Science Foundation Graduate Research Fellowship (grant number 00039202). TEM imaging in this study was carried out in the Characterization Facility, University of Minnesota, which receives partial support from the National Science Foundation through the MRSEC program. The authors gratefully acknowledge Fang Zhou at the Characterization Facility for microtome preparation of resin-embedded samples for TEM. The authors thank Elizabeth Lundstrom for ICP-MS analysis of the ion dissolution samples in bacterial medium as part of the University of Minnesota Earth Sciences Department. The authors acknowledge the Trace Element Research Group at the UW-Madison, Wisconsin State Laboratory of Hygiene (WSLH) for their analytical services (magnetic-sector ICPMS) for the ion dissolution samples in daphnid medium. The authors are thankful to Tianlei Yan for his contributions to NMC synthesis. This research was supported in part through computational resources provided by the University of Iowa, Iowa City, Iowa. This work used the Extreme Science and Engineering Discovery Environment (XSEDE59), which is supported by National Science Foundation grant number ACI-1548562 through allocation ID TG-GEO160006.

How much support was provided by MRSEC?

  • Shared


Dive into the research topics of 'Nickel enrichment of next-generation NMC nanomaterials alters material stability, causing unexpected dissolution behavior and observed toxicity to: S. oneidensis MR-1 and D. magna'. Together they form a unique fingerprint.

Cite this