Nickel-Catalyzed Oxidative Decarboxylative (Hetero)Arylation of Unactivated C-H Bonds: Ni and Ag Synergy

Aaron P. Honeycutt, Jessica M. Hoover

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Oxidative decarboxylative arylation reactions are potentially attractive routes to generate biaryl structures from simple and readily available precursors; yet, they are underutilized, because of limitations in the carboxylic acid scope. Here, we report a nickel catalyst system that enables the selective decarboxylative arylation of unactivated C-H bonds with a broad scope of (hetero)aromatic carboxylate coupling partners. Preliminary mechanistic insights suggest that the efficiency and selectivity of this protocol originate from cooperation between Ni and Ag.

Original languageEnglish (US)
Pages (from-to)4597-4601
Number of pages5
JournalACS Catalysis
Issue number7
StatePublished - Jul 7 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.


  • C-H activation
  • decarboxylation
  • heteroaryl
  • nickel
  • silver


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