Nickel-Catalyzed Oxidative Decarboxylative Annulation for the Synthesis of Heterocycle-Containing Phenanthridinones

Aaron P. Honeycutt; Jessica M. Hoover

doi:10.1021/acs.orglett.8b03144

Nickel-Catalyzed Oxidative Decarboxylative Annulation for the Synthesis of Heterocycle-Containing Phenanthridinones

Aaron P. Honeycutt, Jessica M. Hoover

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A nickel-catalyzed oxidative decarboxylative annulation reaction of simple benzamides and (hetero)aromatic carboxylates has been developed. This reaction provides access to a large array of phenanthridinones and their heterocyclic analogues, highlighting the utility and versatility of oxidative decarboxylative coupling strategies for C-C bond formation.

Original language	English (US)
Pages (from-to)	7216-7219
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	22
DOIs	https://doi.org/10.1021/acs.orglett.8b03144
State	Published - Nov 16 2018
Externally published	Yes

Bibliographical note

Funding Information:
We are grateful to the NSF (CHE-1454879), the NIH (1R15GM126514-01), and West Virginia University for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336).

Publisher Copyright:
© 2018 American Chemical Society.

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abstract = "A nickel-catalyzed oxidative decarboxylative annulation reaction of simple benzamides and (hetero)aromatic carboxylates has been developed. This reaction provides access to a large array of phenanthridinones and their heterocyclic analogues, highlighting the utility and versatility of oxidative decarboxylative coupling strategies for C-C bond formation.",

author = "Honeycutt, {Aaron P.} and Hoover, {Jessica M.}",

note = "Funding Information: We are grateful to the NSF (CHE-1454879), the NIH (1R15GM126514-01), and West Virginia University for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336). Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

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doi = "10.1021/acs.orglett.8b03144",

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AU - Honeycutt, Aaron P.

AU - Hoover, Jessica M.

N1 - Funding Information: We are grateful to the NSF (CHE-1454879), the NIH (1R15GM126514-01), and West Virginia University for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336). Publisher Copyright: © 2018 American Chemical Society.

PY - 2018/11/16

Y1 - 2018/11/16

N2 - A nickel-catalyzed oxidative decarboxylative annulation reaction of simple benzamides and (hetero)aromatic carboxylates has been developed. This reaction provides access to a large array of phenanthridinones and their heterocyclic analogues, highlighting the utility and versatility of oxidative decarboxylative coupling strategies for C-C bond formation.

AB - A nickel-catalyzed oxidative decarboxylative annulation reaction of simple benzamides and (hetero)aromatic carboxylates has been developed. This reaction provides access to a large array of phenanthridinones and their heterocyclic analogues, highlighting the utility and versatility of oxidative decarboxylative coupling strategies for C-C bond formation.

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Nickel-Catalyzed Oxidative Decarboxylative Annulation for the Synthesis of Heterocycle-Containing Phenanthridinones

Abstract

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