Newborn Sepsis and Meningitis

Patricia Ferrieri, Linda D. Wallen

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


• Group B streptococcus and Escherichia coli account for most of the cases of neonatal early-onset bacterial sepsis. • Prevention of infection by maternal treatment is the main factor accounting for the decreased incidence of early-onset group B streptococcus sepsis. • Microbiologic cultures represent the mainstay for diagnosis of infection. • Management of the asymptomatic newborn at risk of infection because of maternal risk factors is in transition, with recent evidence supporting evaluation and treatment of a small proportion of asymptomatic infants. • Ampicillin and gentamicin are recommended as initial therapy in neonates with suspected bacterial sepsis. Treatment can then be narrowed appropriately on the basis of the results of antibiotic susceptibility studies.

Original languageEnglish (US)
Title of host publicationAvery's Diseases of the Newborn, Tenth Edition
ISBN (Electronic)9780323401395
ISBN (Print)9780323401739
StatePublished - Jan 1 2017

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc. All rights reserved.


  • E coli
  • Neonatal sepsis
  • Risk factors for neonatal sepsis
  • Streptococcus, Group B
  • Treatment of neonatal sepsis


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