New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity

Shengmin Sang, Guangming Liu, Kan He, Nanqun Zhu, Zigang Dong, Qunyi Zheng, Robert T. Rosen, Chi Tang Ho

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A novel iridoid dimer in whose structure the two iridoid units are connected by a rare ether group, together with two new unusual iridoids showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, have been isolated from the leaves of noni (Morinda citrifolia L.). Their structures were determined on the basis of detailed high-field 1D and 2D spectral analysis. Their inhibitory effect on UVB-induced transcriptional Activator Protein-1 (AP-1) activity are also discussed.

Original languageEnglish (US)
Pages (from-to)2499-2502
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume11
Issue number12
DOIs
StatePublished - Jun 12 2003

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