New therapeutic strategies for heart failure: left ventricular remodeling as a target.

Jay N. Cohn

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Structural remodeling of the left ventricle involves myocyte growth and matrix changes that result in chamber enlargement, contractile dysfunction and dyssynchrony. Clinical and experimental data document that these structural changes correlate with progressive worsening of the syndrome of heart failure, that the changes are preventable and reversible, and that a favorable clinical therapeutic response is associated with regression of remodeling. The growing evidence that structural remodeling represents the disease of heart failure has now fueled mechanical as well as pharmacologic approaches to inhibiting the remodeling.

Original languageEnglish (US)
Pages (from-to)S200-201
JournalJournal of cardiac failure
Volume10
Issue number6 Suppl
DOIs
StatePublished - Dec 2004

Fingerprint Dive into the research topics of 'New therapeutic strategies for heart failure: left ventricular remodeling as a target.'. Together they form a unique fingerprint.

Cite this