TY - JOUR
T1 - New therapeutic strategies for heart failure
T2 - left ventricular remodeling as a target.
AU - Cohn, Jay N.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2004/12
Y1 - 2004/12
N2 - Structural remodeling of the left ventricle involves myocyte growth and matrix changes that result in chamber enlargement, contractile dysfunction and dyssynchrony. Clinical and experimental data document that these structural changes correlate with progressive worsening of the syndrome of heart failure, that the changes are preventable and reversible, and that a favorable clinical therapeutic response is associated with regression of remodeling. The growing evidence that structural remodeling represents the disease of heart failure has now fueled mechanical as well as pharmacologic approaches to inhibiting the remodeling.
AB - Structural remodeling of the left ventricle involves myocyte growth and matrix changes that result in chamber enlargement, contractile dysfunction and dyssynchrony. Clinical and experimental data document that these structural changes correlate with progressive worsening of the syndrome of heart failure, that the changes are preventable and reversible, and that a favorable clinical therapeutic response is associated with regression of remodeling. The growing evidence that structural remodeling represents the disease of heart failure has now fueled mechanical as well as pharmacologic approaches to inhibiting the remodeling.
UR - http://www.scopus.com/inward/record.url?scp=18444409946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18444409946&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2004.09.007
DO - 10.1016/j.cardfail.2004.09.007
M3 - Review article
C2 - 15803550
AN - SCOPUS:18444409946
SN - 1071-9164
VL - 10
SP - S200-201
JO - Journal of cardiac failure
JF - Journal of cardiac failure
IS - 6 Suppl
ER -