Abstract
Tissue repair is an essential mechanism to maintain the integrity and function of the body in response to a variety of both acute and chronic injuries and disease states. One of the major challenges to achieve clinically meaningful tissue regeneration and repair is a better understanding of the mechanisms involved in both native or endogenous, as well as exogenous stem cell homing of transplanted cells. Both approaches involve a complex network of factors and sequence of events that drive the trafficking and homing of stem cells to the area of injury to optimize repair. This chapter will review the major factors that orchestrate stem cell homing, and discuss a number of new cell and tissue-based strategies to improve the homing, engraftment, and efficacy of cell therapy.
| Original language | English (US) |
|---|---|
| Title of host publication | Stem Cell and Gene Therapy for Cardiovascular Disease |
| Publisher | Elsevier Science, Ltd., Press |
| Pages | 485-496 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780128018637 |
| ISBN (Print) | 9780128018880 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
Keywords
- Cell and tissue preconditioning
- Chemokines in tissue repair
- Endogenous and exogenous tissue repair
- Paracrine signaling
- Stem cell homing