New strategies and challenges in lung proteomics and metabolomics: An official American thoracic society workshop report

Russell P. Bowler, Chris H. Wendt, Michael B. Fessler, Matthew W. Foster, Rachel S. Kelly, Jessica Lasky-Su, Angela J. Rogers, Kathleen A. Stringer, Brent W. Winston

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

This document presents the proceedings from the workshop entitled, "New Strategies and Challenges in Lung Proteomics and Metabolomics" held February 4th-5th, 2016, in Denver, Colorado. It was sponsored by the National Heart Lung Blood Institute, the American Thoracic Society, the Colorado Biological Mass Spectrometry Society, and National Jewish Health. The goal of this workshop was to convene, for the first time, relevant experts in lung proteomics and metabolomics to discuss and overcome specific challenges in these fields that are unique to the lung. The main objectives of this workshop were to identify, review, and/or understand: (1) emerging technologies in metabolomics and proteomics as applied to the study of the lung; (2) the unique composition and challenges of lung-specific biological specimens for metabolomic and proteomic analysis; (3) the diverse informatics approaches and databases unique to metabolomics and proteomics, with special emphasis on the lung; (4) integrative platforms across genetic and genomic databases that can be applied to lung-related metabolomic and proteomic studies; and (5) the clinical applications of proteomics and metabolomics. The major findings and conclusions of this workshop are summarized at the end of the report, and outline the progress and challenges that face these rapidly advancing fields.

Original languageEnglish (US)
Pages (from-to)1721-1743
Number of pages23
JournalAnnals of the American Thoracic Society
Volume14
Issue number12
DOIs
StatePublished - Dec 2017

Bibliographical note

Publisher Copyright:
Copyright © 2017 by the American Thoracic Society.

Keywords

  • Biomarkers
  • Lung Diseases
  • Mass Spectrometry
  • Nuclear Magnetic Resonance
  • Systems Biology

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