New routes to conformationally restricted peptide building blocks: A convenient preparation of bicyclic piperazinone derivatives

Yvette M. Fobian, D. André D'Avignon, Kevin D. Moeller

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

A facile route for the synthesis of peptide building blocks that constrain the peptide backbone with a 1,4-diazabicyclo[4.3.0]nonane ring skeleton is reported. The synthesis employed an anodic amide oxidation based approach for generating a functionalized proline derivative, and then utilized the derivative as a general substrate for rapidly assembling the bicyclic ring system.

Original languageEnglish (US)
Pages (from-to)315-318
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

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