New oral anticoagulants in surgery

Jihane Abou Rahal; Zaher K. Otrock; Joseph E. Maakaron; Ali Taher

doi:10.1007/978-1-4471-2912-7_22

New oral anticoagulants in surgery

Jihane Abou Rahal, Zaher K. Otrock, Joseph E. Maakaron, Ali Taher

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

For over 50 years, the only available oral anticoagulants for the treatment and prevention of thromboembolic diseases have been vitamin K antagonists (VKA) such as warfarin. Although highly effective, VKAs have many disadvantages: they have a narrow therapeutic range with a subsequent need for frequent monitoring, a >10-fold interindividual variation in dose-response, and numerous interactions with drugs and food. Thus, antithrombotics have been developed, and they emerged to circumvent these problems and limitations.

Original language	English (US)
Title of host publication	Vascular Surgery
Publisher	Springer London
Pages	331-338
Number of pages	8
ISBN (Electronic)	9781447129127
ISBN (Print)	9781447129110
DOIs	https://doi.org/10.1007/978-1-4471-2912-7_22
State	Published - Jan 1 2012
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer-Verlag London 2012. All rights reserved.

Keywords

Apixaban
Dabigatran
Oral anticoagulants
Rivaroxaban
Venous thromboembolic disease

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10.1007/978-1-4471-2912-7_22

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abstract = "For over 50 years, the only available oral anticoagulants for the treatment and prevention of thromboembolic diseases have been vitamin K antagonists (VKA) such as warfarin. Although highly effective, VKAs have many disadvantages: they have a narrow therapeutic range with a subsequent need for frequent monitoring, a >10-fold interindividual variation in dose-response, and numerous interactions with drugs and food. Thus, antithrombotics have been developed, and they emerged to circumvent these problems and limitations.",

keywords = "Apixaban, Dabigatran, Oral anticoagulants, Rivaroxaban, Venous thromboembolic disease",

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AU - Maakaron, Joseph E.

AU - Taher, Ali

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Y1 - 2012/1/1

N2 - For over 50 years, the only available oral anticoagulants for the treatment and prevention of thromboembolic diseases have been vitamin K antagonists (VKA) such as warfarin. Although highly effective, VKAs have many disadvantages: they have a narrow therapeutic range with a subsequent need for frequent monitoring, a >10-fold interindividual variation in dose-response, and numerous interactions with drugs and food. Thus, antithrombotics have been developed, and they emerged to circumvent these problems and limitations.

AB - For over 50 years, the only available oral anticoagulants for the treatment and prevention of thromboembolic diseases have been vitamin K antagonists (VKA) such as warfarin. Although highly effective, VKAs have many disadvantages: they have a narrow therapeutic range with a subsequent need for frequent monitoring, a >10-fold interindividual variation in dose-response, and numerous interactions with drugs and food. Thus, antithrombotics have been developed, and they emerged to circumvent these problems and limitations.

KW - Apixaban

KW - Dabigatran

KW - Oral anticoagulants

KW - Rivaroxaban

KW - Venous thromboembolic disease

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M3 - Chapter

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SP - 331

EP - 338

BT - Vascular Surgery

PB - Springer London

ER -

New oral anticoagulants in surgery

Abstract

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Keywords

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