New onset of type 2 diabetes mellitus with feminizing hormone therapy: Case series

The effects of hormone therapy on glucose tolerance in male-to-female transgender patients have not been specifically addressed in the medical literature. Three cases of new onset type 2 diabetes mellitus during the course of feminizing therapy are examined in light of current literature regarding sex hormones and glucose tolerance. Feminizing therapy may contribute to the onset of diabetes in male-to-female patients with concomitant risk factors. Further research is needed to evaluate the effect of feminizing regimens on glucose tolerance, and to elucidate which patients may benefit from regular screening during the course of therapy.