New mode of drug delivery: Long term autonomous rhythmic hormone release across a hydrogel membrane

Gauri P. Misra; Ronald A. Siegel

doi:10.1016/S0168-3659(02)00043-3

New mode of drug delivery: Long term autonomous rhythmic hormone release across a hydrogel membrane

Gauri P. Misra, Ronald A. Siegel

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

This note demonstrates a novel mode of rhythmic drug delivery, which is independent of external modulation or physiological stimulation. Rhythmic behavior is attributed to negative, nonlinear feedback between the swelling state of a hydrogel membrane and the enzymatic conversion of glucose to hydrogen ion. The system pulsates in the presence of a constant level of glucose, thus distinguishing it from insulin delivery devices that respond to changes in glucose concentration. As an example, gonadotropin-releasing hormone (GnRH) was released in short, repetitive pulses over 1 week.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Journal of Controlled Release
Volume	81
Issue number	1-2
DOIs	https://doi.org/10.1016/S0168-3659(02)00043-3
State	Published - May 17 2002

Bibliographical note

Funding Information:
This work was funded by NSF grant CHE-9996223. We thank Anish P. Dhanarajan and Yuandong Gu for helpful comments.

Keywords

Feedback
GnRH
Hormone
Hydrogel
LHRH
Rhythmic delivery
Ultradian

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10.1016/S0168-3659(02)00043-3

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title = "New mode of drug delivery: Long term autonomous rhythmic hormone release across a hydrogel membrane",

abstract = "This note demonstrates a novel mode of rhythmic drug delivery, which is independent of external modulation or physiological stimulation. Rhythmic behavior is attributed to negative, nonlinear feedback between the swelling state of a hydrogel membrane and the enzymatic conversion of glucose to hydrogen ion. The system pulsates in the presence of a constant level of glucose, thus distinguishing it from insulin delivery devices that respond to changes in glucose concentration. As an example, gonadotropin-releasing hormone (GnRH) was released in short, repetitive pulses over 1 week.",

keywords = "Feedback, GnRH, Hormone, Hydrogel, LHRH, Rhythmic delivery, Ultradian",

author = "Misra, \{Gauri P.\} and Siegel, \{Ronald A.\}",

note = "Funding Information: This work was funded by NSF grant CHE-9996223. We thank Anish P. Dhanarajan and Yuandong Gu for helpful comments.",

year = "2002",

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T2 - Long term autonomous rhythmic hormone release across a hydrogel membrane

AU - Misra, Gauri P.

AU - Siegel, Ronald A.

N1 - Funding Information: This work was funded by NSF grant CHE-9996223. We thank Anish P. Dhanarajan and Yuandong Gu for helpful comments.

PY - 2002/5/17

Y1 - 2002/5/17

N2 - This note demonstrates a novel mode of rhythmic drug delivery, which is independent of external modulation or physiological stimulation. Rhythmic behavior is attributed to negative, nonlinear feedback between the swelling state of a hydrogel membrane and the enzymatic conversion of glucose to hydrogen ion. The system pulsates in the presence of a constant level of glucose, thus distinguishing it from insulin delivery devices that respond to changes in glucose concentration. As an example, gonadotropin-releasing hormone (GnRH) was released in short, repetitive pulses over 1 week.

AB - This note demonstrates a novel mode of rhythmic drug delivery, which is independent of external modulation or physiological stimulation. Rhythmic behavior is attributed to negative, nonlinear feedback between the swelling state of a hydrogel membrane and the enzymatic conversion of glucose to hydrogen ion. The system pulsates in the presence of a constant level of glucose, thus distinguishing it from insulin delivery devices that respond to changes in glucose concentration. As an example, gonadotropin-releasing hormone (GnRH) was released in short, repetitive pulses over 1 week.

KW - Feedback

KW - GnRH

KW - Hormone

KW - Hydrogel

KW - LHRH

KW - Rhythmic delivery

KW - Ultradian

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AN - SCOPUS:0037123725

SN - 0168-3659

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 1-2

ER -

New mode of drug delivery: Long term autonomous rhythmic hormone release across a hydrogel membrane

Abstract

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Keywords

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