New mode of drug delivery: Long term autonomous rhythmic hormone release across a hydrogel membrane

Gauri P. Misra, Ronald A. Siegel

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

This note demonstrates a novel mode of rhythmic drug delivery, which is independent of external modulation or physiological stimulation. Rhythmic behavior is attributed to negative, nonlinear feedback between the swelling state of a hydrogel membrane and the enzymatic conversion of glucose to hydrogen ion. The system pulsates in the presence of a constant level of glucose, thus distinguishing it from insulin delivery devices that respond to changes in glucose concentration. As an example, gonadotropin-releasing hormone (GnRH) was released in short, repetitive pulses over 1 week.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Controlled Release
Volume81
Issue number1-2
DOIs
StatePublished - May 17 2002

Bibliographical note

Funding Information:
This work was funded by NSF grant CHE-9996223. We thank Anish P. Dhanarajan and Yuandong Gu for helpful comments.

Keywords

  • Feedback
  • GnRH
  • Hormone
  • Hydrogel
  • LHRH
  • Rhythmic delivery
  • Ultradian

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