New insights into cystic fibrosis-related diabetes in children

Katie L. Ode, Antoinette Moran

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Cystic fibrosis-related diabetes (CFRD) is the most common complication of cystic fibrosis. It is associated with significantly increased morbidity and mortality in adults and children. Adolescents with cystic fibrosis have a much higher prevalence of diabetes than any other similar age population. Glucose abnormalities that precede diabetes are even more common, especially in children younger than 10 years. The pathophysiology of glucose metabolic abnormalities is poorly understood, but insulin insufficiency is clearly the main component. Findings from animal studies have provided insight into the pathophysiology of CFRD, and imply that carbohydrate metabolic abnormalities might begin at much younger ages than was previously thought in patients with cystic fibrosis, and might be related to the basic cystic fibrosis chloride channel defect. In this Review we explore present knowledge of CFRD in children and adolescents, and new data that indicate that the pathophysiology of CFRD begins in very young patients.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalThe Lancet Diabetes and Endocrinology
Volume1
Issue number1
DOIs
StatePublished - Sep 2013

Fingerprint Dive into the research topics of 'New insights into cystic fibrosis-related diabetes in children'. Together they form a unique fingerprint.

Cite this