The aerial parts of Fagonia boveana afforded two new erythroxane-type diterpenes, 3β, 15, 16-trihydroxy-erythrox-4(18)-ene (2) and 15, 16-dihydroxy-cis-ent-erythrox-3-ene (fagonene) (3) together with two known ones; 16-O-acetylfagonone (1) and 7β-hydroxy fagonene (8). Also a new guaiane sesquiterpene alcohol, 6,10-epoxy-4α-hydroxy guaiane type sesquiterpene (4) has been isolated In addition three 8-methoxy flavonols, 8-methoxy-quercetin-3, 7, 3′-trimethyl ether (ternatin) (5), gossypetin, 3, 8, 3′, 4′ tetramethyl ether (6) and herbacetin-3, 8-dimethyl ether (7) were also isolated. The structures of the isolated compounds have been determined on the basis of spectroscopic evidences as well as physical and chemical correlation with known compounds. On performing different assays for biological activities, 6 displayed significant cytotoxic activity against KA3IT and NIH3T3 cell lines, 8 was the most active antiviral against Herpes simplex type 1 while 7 was the most active cancer-preventive agent using protein-tyrosine kinase inhibitory method.
|Original language||English (US)|
|Number of pages||10|
|Journal||Zeitschrift fur Naturforschung - Section C Journal of Biosciences|
|State||Published - Feb 2003|
- Cytotoxic Assays
- Fagonia boveana