New disc-based technologies for diagnostic and research applications

Raj Barathur, Jack Bookout, Srinand Sreevatsan, John Gordon, Martina Werner, Gautam Thor, Mark Worthington

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

The role of genotypic analysis in disease diagnostics and drug response assessment is continually expanding. New genomic discoveries combined with new, novel technologies may provide a greater range of testing capabilities in the near future. We describe the application of nanotechnology, in which DNA microarrays have been placed in a microchannel environment that can be read and analyzed in an optical (CD/DVD) disc drive system. The potential exists to combine molecular and immunological applications together into a rapid, low-cost, high-capacity screening platform. The relevance of this technology is discussed in respect to infectious agent detection, pharmacogenomics, neurogenomics and genetic variations associated with neurologic diseases.

Original languageEnglish (US)
Pages (from-to)193-206
Number of pages14
JournalPsychiatric Genetics
Volume12
Issue number4
DOIs
StatePublished - Dec 1 2002

Keywords

  • CD/DVD discs
  • Gene variants
  • Genotyping
  • MEMS
  • Microarrays
  • Nanotechnology
  • Neurogenomics
  • Neurologic disorders
  • Optical discs
  • Pathogen detection
  • Pharmacogenomics

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