New directions in cellular therapy of cancer: A summary of the summit on cellular therapy for cancer

David F. Stroncek, Carolina Berger, Martin A. Cheever, Richard W. Childs, Mark E. Dudley, Peter Flynn, Luca Gattinoni, James R. Heath, Michael Kalos, Francesco M. Marincola, Jeffrey S. Miller, Gustavo Mostoslavsky, Daniel J. Powell, Mahendra Rao, Nicholas P. Restifo, Steven A. Rosenberg, John O'Shea, Cornelis J.M. Melief

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35 Scopus citations

Abstract

A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly. Conventional cellular therapies, such as tumor infiltrating lymphocytes (TIL), are becoming more effective and more available. Gene therapy is becoming an important tool in adoptive cell therapy. Lymphocytes are being engineered to express high affinity T cell receptors (TCRs), chimeric antibody-T cell receptors (CARs) and cytokines. T cell subsets with more naïve and stem cell-like characteristics have been shown in pre-clinical models to be more effective than unselected populations and it is now possible to reprogram T cells and to produce T cells with stem cell characteristics. In the future, combinations of adoptive transfer of T cells and specific vaccination against the cognate antigen can be envisaged to further enhance the effectiveness of these therapies.

Original languageEnglish (US)
Article number48
JournalJournal of Translational Medicine
Volume10
Issue number1
DOIs
StatePublished - Mar 15 2012

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