New developments in bacterial resistance mediated by beta-lactamases

J. S. Bakken, C. C. Sanders

Research output: Contribution to journalArticlepeer-review


Bacteria may resist the action of beta-lactam antibiotics by several mechanisms. Production of beta-lactamase is by far the most commonly encountered mechanism. Despite the fact that there are beta-lactam compounds that resist hydrolysis by beta-lactamases, certain gram-negative bacteria rapidly develop resistance to these agents. This resistance has been shown to be due to derepression of chromosomal Class I beta-lactamases. Emergence of resistance during therapy with the newer beta-lactams has become a significant problem in nosocomial infections. The indiscriminate use of expanded-spectrum beta-lactams should be avoided to minimize the therapeutic problems posed by this resistance as well as the ecological impact of broad-spectrum beta-lactam resistance on the hospital environment.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalISI Atlas of Science: Pharmacology
Issue number2
StatePublished - Jan 1 1987


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