New cylindrical peptide assemblies defined by extended parallel β-sheets

Ashok D. Pehere, Christopher J. Sumby, Andrew D. Abell

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A new approach to non-covalent peptide-based nanotubular or rod-like structures is presented, whereby the monomeric units are preorganised into a β-strand geometry that templates the formation of an extended and unusual parallel β-sheet rod-like structure. The conformational constraint is introduced by Huisgen cycloaddition to give a triazole-based macrocycle, with the resulting self-assembled structures stabilized by a well-defined series of intermolecular hydrogen bonds.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number3
DOIs
StatePublished - Jan 21 2013

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