New charts for the assessment of body composition, according to air-displacement plethysmography, at birth and across the first 6 mo of life

Tom Norris, Sara E. Ramel, Patrick Catalano, Carol ni Caoimh, Paola Roggero, Deirdre Murray, David A. Fields, Ellen W. Demerath, William Johnson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: Air-displacement plethysmography (ADP) is a good candidate for monitoring body composition in newborns and young infants, but reference centile curves are lacking that allow for assessment at birth and across the first 6 mo of life. Objectives: Using pooled data from 4 studies, we aimed to produce new charts for assessment according to gestational age at birth (30 + 1 to 41 + 6 wk) and postnatal age at measurement (1-27 wk). Methods: The sample comprised 222 preterm infants born in the United States who were measured at birth; 1029 term infants born in Ireland who were measured at birth; and 149 term infants born in the United States and 57 term infants born in Italy who were measured at birth, 1 and 2 wk, and 1, 2, 3, 4, 5, and 6 mo of age. Infants whose birth weights were <3rd or >97th centile of the INTERGROWTH-21st standard were excluded, thereby ensuring that the charts depict body composition of infants whose birth weights did not indicate suboptimal fetal growth. Sex-specific centiles for fat mass (kg), fat-free mass (kg), and percentage body fat were estimated using the lambda-mu-sigma (LMS) method. Results: For each sex and measure (e.g., fat mass), the new charts comprised 2 panels. The first showed centiles according to gestational age, allowing term infants to be assessed at birth and preterm infants to be monitored until they reached term. The second showed centiles according to postnatal age, allowing all infants to be monitored to age 27 wk. The LMS values underlying the charts were presented, enabling researchers and clinicians to convert measurements to centiles and z scores. Conclusions: The new charts provide a single tool for the assessment of body composition, according to ADP, in infants across the first 6 mo of life and will help enhance early-life nutritional management.

Original languageEnglish (US)
Pages (from-to)1353-1360
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume109
Issue number5
DOIs
StatePublished - May 1 2019

Bibliographical note

Funding Information:
The Cork BASELINE study and Prof Deirdre Murray are funded by the National Children’s Research Centre, Dublin, Ireland. WJ is supported by a UK Medical Research Council (MRC) New Investigator Research Grant (MR/P023347/1) and acknowledges support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University, and the University of Leicester.

Funding Information:
This secondary data analysis project was funded in part by COSMED, Inc. COSMED, Inc. was not involved in the statistical analysis, interpretation of the data, or manuscript preparation and writing.

Funding Information:
The Cork BASELINE study and Prof Deirdre Murray are funded by the National Children's Research Centre, Dublin, Ireland. WJ is supported by a UK Medical Research Council (MRC) New Investigator Research Grant (MR/P023347/1) and acknowledges support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University, and the University of Leicester.

Publisher Copyright:
Copyright © American Society for Nutrition 2019. All rights reserved.

Keywords

  • Air-displacement plethysmography
  • Body composition
  • Centiles
  • Infant
  • Reference charts

Fingerprint

Dive into the research topics of 'New charts for the assessment of body composition, according to air-displacement plethysmography, at birth and across the first 6 mo of life'. Together they form a unique fingerprint.

Cite this