Abstract
A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 555-559 |
| Number of pages | 5 |
| Journal | Planta Medica |
| Volume | 74 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 2008 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Bromotyrosine alkaloids
- Hyphae formation inhibition
- Marine sponge, Aplysinella sp.
- Protein phosphorylation inhibitors
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