New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

Frank Joy Ankudey; Paul Kiprof; Emily R. Stromquist; Chee Chang Leng

doi:10.1055/s-2008-1074506

New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

Frank Joy Ankudey, Paul Kiprof, Emily R. Stromquist, Chee Chang Leng

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

Original language	English (US)
Pages (from-to)	555-559
Number of pages	5
Journal	Planta Medica
Volume	74
Issue number	5
DOIs	https://doi.org/10.1055/s-2008-1074506
State	Published - Apr 2008

Keywords

Bromotyrosine alkaloids
Hyphae formation inhibition
Marine sponge, Aplysinella sp.
Protein phosphorylation inhibitors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1055/s-2008-1074506

Find It

Find It at U of M Libraries

Cite this

@article{a48dfe067e5e4cbe8dc8e0befa3d4d7e,

title = "New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.",

abstract = "A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.",

keywords = "Bromotyrosine alkaloids, Hyphae formation inhibition, Marine sponge, Aplysinella sp., Protein phosphorylation inhibitors",

author = "Ankudey, {Frank Joy} and Paul Kiprof and Stromquist, {Emily R.} and Leng, {Chee Chang}",

year = "2008",

month = apr,

doi = "10.1055/s-2008-1074506",

language = "English (US)",

volume = "74",

pages = "555--559",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "5",

}

TY - JOUR

T1 - New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

AU - Ankudey, Frank Joy

AU - Kiprof, Paul

AU - Stromquist, Emily R.

AU - Leng, Chee Chang

PY - 2008/4

Y1 - 2008/4

N2 - A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

AB - A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

KW - Bromotyrosine alkaloids

KW - Hyphae formation inhibition

KW - Marine sponge, Aplysinella sp.

KW - Protein phosphorylation inhibitors

UR - http://www.scopus.com/inward/record.url?scp=43249110984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43249110984&partnerID=8YFLogxK

U2 - 10.1055/s-2008-1074506

DO - 10.1055/s-2008-1074506

M3 - Article

C2 - 18401846

AN - SCOPUS:43249110984

SN - 0032-0943

VL - 74

SP - 555

EP - 559

JO - Planta Medica

JF - Planta Medica

IS - 5

ER -

New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

Abstract

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this