New and TALENted genome engineering toolbox

Jarryd M. Campbell, Katherine A. Hartjes, Timothy J. Nelson, Xiaolei Xu, Stephen C. Ekker

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are transforming our understanding of personalized medicine with an emphasis on cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)571-587
Number of pages17
JournalCirculation research
Volume113
Issue number5
DOIs
StatePublished - Aug 16 2013

Keywords

  • TALENs
  • cardiovascular disease modeling
  • genome engineering
  • induced pluripotent stem cells
  • zebrafish

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