New advances in ligand design for synthetic modeling of metalloprotein active sites

William B. Tolman, Douglas J.E. Spencer

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Judicious control of ligand steric bulk and auxiliary structural elements enables the construction of novel synthetic complexes that model the properties of metalloprotein active sites, thus providing insight into their structure and function. Major recent developments include the synthesis of a number of unusual and biologically relevant complexes of copper and iron using elaborate N-donor and O-donor ligands.

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalCurrent opinion in chemical biology
Volume5
Issue number2
DOIs
StatePublished - Apr 1 2001

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