New 26S proteasome inhibitors with high selectivity for chymotrypsin-like activity and p53-dependent cytotoxicity

Keyphrases

• Cytotoxicity 100%
• High Selectivity 100%
• Protease Inhibitors 100%
• Chymotrypsin 100%
• 26S Proteasome Inhibitors 100%
• Therapeutic Target 33%
• Bortezomib 33%
• Cancer Treatment 33%
• Tumor Suppressor 33%
• Protease 33%
• Cell Death 33%
• In Vitro Activity 33%
• Aldehydes 33%
• Anticancer Activity 33%
• Sarcoma Cells 33%
• High Specificity 33%
• P53 Pathway 33%
• Cytotoxic Activity 33%
• Catalytic Activity 33%
• Tripeptide 33%
• 26S Proteasome 33%
• High Potency 33%
• Decreased Activity 33%
• MG132 33%
• Proteasomal Inhibition 33%
• Therapeutic Window 33%
• Strand Geometry 33%
• Peptide Backbone 33%

Biochemistry, Genetics and Molecular Biology

• Proteasome Inhibitor 100%
• Cytotoxicity 100%
• P53 100%
• Chymotrypsin 100%
• Proteasome 50%
• Tumor Suppressor Protein 25%
• Enzymatic Activity 25%
• MG132 25%
• Mediator 25%
• Antineoplastic Activity 25%
• Cell Death 25%
• Protease 25%
• Tripeptide 25%