Neutrophil gelatinase-associated lipocalin as a biomarker for predicting acute kidney injury during off-pump coronary artery bypass grafting

Muralidhar Kanchi, R. Manjunath, Jos Massen, Lloyd Vincent, Kumar Belani

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Acute kidney injury (AKI) following cardiac surgery is a major complication resulting in increased morbidity, mortality, and economic burden. In this study, we assessed the usefulness of estimating serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker in predicting AKI in patients with stable chronic kidney disease (CKD) and undergoing off-pump coronary artery bypass grafting (OP-CABG). Patients and Methods: We prospectively studied sixty nondialysis-dependent CKD patients with estimated glomerular filtration rate <60 ml/min/1.73 m2 who required elective OP-CABG. Patients were randomized into two groups, Group D received dopamine infusion at 2 μg/kg/min following anesthesia induction till the end of the surgery and Group P did not receive any intervention. Serum creatinine, NGAL, brain natriuretic peptide, and troponin-I were estimated at specified intervals before, during, and after surgery. The results of the study patients were also compared to a simultaneous matched cohort control of thirty patients (Group A) without renal dysfunction who underwent OP-CABG. Results: No patient required renal replacement therapy, and no mortality was observed during perioperative and hospitalization period. Six patients from control group (n = 30), ten patients from placebo group (n = 30), and 12 patients from dopamine group (n = 30) developed stage 1 AKI. However, we did not observe any stage 2 and stage 3 AKI among all the groups. There was a significant increase in serum NGAL levels at the end of surgery and 24 h postoperatively in placebo and dopamine groups as compared to the control. Conclusion: The measurement of NGAL appears to predict the occurrence of AKI after OP-CAB surgery. However, large multicentric studies may be required to confirm the findings of this study.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalAnnals of Cardiac Anaesthesia
Volume20
Issue number3
DOIs
StatePublished - Jul 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Annals of Cardiac Anaesthesia Published by Wolters Kluwer - Medknow.

Keywords

  • Acute kidney injury
  • cardiac surgery
  • coronary artery bypass grafting
  • creatinine
  • dopamine
  • neutrophil gelatinase-associated lipocalin

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