Neutropenia in pediatric solid organ transplant

Lyndsay A. Harshman, Robin Williams, Rachel M. Engen

Research output: Contribution to journalReview articlepeer-review

Abstract

Neutropenia is generally defined as an absolute neutrophil count in the circulation of less than 1500/mm3 and occurs in up to 25%–30% of pediatric solid organ transplant recipients (SOT) within the first year after transplantation. In the SOT population, neutropenia is most often a result of drug-induced bone marrow suppression but can also be secondary to viral infection, nutritional deficiencies, lymphoproliferative infiltrate, and inherited causes. Outcomes for patients with neutropenia vary by degree of neutropenia and type of solid organ transplant. Management of neutropenia should begin by addressing the underlying cause, including reducing or removing medications when appropriate, treating infections, and addressing nutrient deficiencies; however, consultation with an experienced pediatric hematologist and use of granulocyte colony-stimulating factor (G-CSF) may be helpful in some cases. Overall, data on clinical outcomes for G-CSF use remain limited, but observational studies may support its use in patients with infections or severe neutropenia.

Original languageEnglish (US)
Article numbere14378
JournalPediatric transplantation
Volume26
Issue number8
DOIs
StatePublished - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC.

Keywords

  • neutropenia
  • pediatric
  • side effects
  • solid organ transplant

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