Neutralization of bacteria- and endotoxin-induced hypotension by lipoprotein-free human serum

A. M. Abdelnoor, N. R. Harvie, A. G. Johnson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Normal human serum and a fraction rich in lipoprotein, Cohn fraction IV1, have been shown in previous studies to detoxify native endotoxin by decreasing lethality for mice, fever in rabbits, and by the alteration of the characteristic endotoxin-anti-endotoxin precipitin pattern in gels. These studies are extended herein and document the ability of normal human serum and fraction IV1 to neutralize the induction of hypotension in rabbits by viable gram-negative bacilli. Further fractionation of serum, using an ultracentrifugal flotation method for producing lipoprotein-free human serum and purified high-density lipoproteins, revealed the lipoprotein-free fraction to be capable of inhibiting endotoxin hypotensive activity and to alter diffusion of endotoxin in gels. On the other hand, the purified high-density lipoproteins failed to negate either activity.

Original languageEnglish (US)
JournalInfection and immunity
Volume38
Issue number1
StatePublished - Jan 1 1982

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Controlled Hypotension
Endotoxins
Lipoproteins
Bacteria
Serum
HDL Lipoproteins
Gels
Rabbits
Precipitins
Hypotension
Bacillus
Fever

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Neutralization of bacteria- and endotoxin-induced hypotension by lipoprotein-free human serum. / Abdelnoor, A. M.; Harvie, N. R.; Johnson, A. G.

In: Infection and immunity, Vol. 38, No. 1, 01.01.1982.

Research output: Contribution to journalArticle

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