Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Joao Prola Netto, Jeffrey Iliff, Danica Stanimirovic, Kenneth A. Krohn, Bronwyn Hamilton, Csanad Varallyay, Seymur Gahramanov, Heike Daldrup-Link, Christopher D'Esterre, Berislav Zlokovic, Haris Sair, Yueh Lee, Saeid Taheri, Rajan Jain, Ashok Panigrahy, Daniel S. Reich, Lester R. Drewes, Mauricio Castillo, Edward A. Neuwelt

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.

Original languageEnglish (US)
Pages (from-to)770-780
Number of pages11
Issue number6
StatePublished - Jun 1 2018

Bibliographical note

Publisher Copyright:
© 2017 by the Congress of Neurological Surgeons.


  • Blood-brain barrier
  • Imaging
  • Neurovascular unit


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