Neuropsychological profile in adult schizophrenia measured with the CMINDS

Theo G M van Erp, Adrian Preda, Jessica A. Turner, Shawn Callahan, Vince D. Calhoun, Juan R. Bustillo, Kelvin O. Lim, Bryon Mueller, Gregory G. Brown, Jatin G. Vaidya, Sarah McEwen, Aysenil Belger, James Voyvodic, Daniel H. Mathalon, Dana Nguyen, Judith M. Ford, Steven G. Potkin

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS®). Neurocognitive domain z-scores were computed from computerized neuropsychological tests, similar to those in the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB), administered to 175 patients with schizophrenia and 169 demographically similar healthy volunteers. The schizophrenia domain profile order by effect size was Speed of Processing (d=-1.14), Attention/Vigilance (d=-1.04), Working Memory (d=-1.03), Verbal Learning (d=-1.02), Visual Learning (d=-0.91), and Reasoning/Problem Solving (d=-0.67). There were no significant group by sex interactions, but overall women, compared to men, showed advantages on Attention/Vigilance, Verbal Learning, and Visual Learning compared to Reasoning/Problem Solving on which men showed an advantage over women. The CMINDS can readily be employed in the assessment of cognitive deficits in neuropsychiatric disorders; particularly in large-scale studies that may benefit most from electronic data capture.

Original languageEnglish (US)
Pages (from-to)826-834
Number of pages9
JournalPsychiatry Research
Volume230
Issue number3
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ireland Ltd.

Keywords

  • MATRICS
  • MCCB
  • Memory
  • Neuropsychology
  • Psychosis
  • Sex
  • Speed of processing

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