Neuropsychological outcomes of U.S. Veterans with report of remote blast-related concussion and current psychopathology

Nathaniel W. Nelson, James B. Hoelzle, Bridget M. Doane, Kathryn A. McGuire, Amanda G. Ferrier-Auerbach, Molly J. Charlesworth, Gregory J. Lamberty, Melissa A. Polusny, Paul A. Arbisi, Scott R. Sponheim

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41 Scopus citations


This study explored whether remote blast-related MTBI and/or current Axis I psychopathology contribute to neuropsychological outcomes among OEF/OIF veterans with varied combat histories. OEF/OIF veterans underwent structured interviews to evaluate history of blast-related MTBI and psychopathology and were assigned to MTBI (n = 18), Axis I (n = 24), Co-morbid MTBI/Axis I (n = 34), or post-deployment control (n = 28) groups. A main effect for Axis I diagnosis on overall neuropsychological performance was identified (F(3,100) = 4.81; p =.004), with large effect sizes noted for the Axis I only (d =.98) and Co-morbid MTBI/Axis I (d =.95) groups relative to the control group. The latter groups demonstrated primary limitations on measures of learning/memory and processing speed. The MTBI only group demonstrated performances that were not significantly different from the remaining three groups. These findings suggest that a remote history of blast-related MTBI does not contribute to objective cognitive impairment in the late stage of injury. Impairments, when present, are subtle and most likely attributable to PTSD and other psychological conditions. Implications for clinical neuropsychologists and future research are discussed.

Original languageEnglish (US)
Pages (from-to)845-855
Number of pages11
JournalJournal of the International Neuropsychological Society
Issue number5
StatePublished - Sep 2012


  • Cognition
  • Mild Traumatic Brain Injury
  • Operation Iraqi Freedom
  • Post-traumatic Stress Disorder


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