Neuropsychological correlates of negative, disorganized and psychotic symptoms in schizophrenia

Michael R. Basso, Henry A. Nasrallah, Stephen C. Olson, Robert A. Bornstein

Research output: Contribution to journalArticlepeer-review

150 Scopus citations

Abstract

Recent studies suggest that three dimensions (negative, disorganized and psychotic) categorize schizophrenic symptoms. A developing literature indicates distinct cerebral correlates of each symptom cluster, but few investigations have determined their neuropsychological correlates. In the present study, the Schedules of Negative and Positive Symptoms measured symptom severity in 62 schizophrenics, and a subsequent principal components analysis revealed three symptom dimensions. Factor scores, age and parental socio-economic status were simultaneously entered into regression equations to explain variance across a broad neuropsychological test battery. Negative symptoms were associated with deficits involving intelligence, executive function, memory, sustained-attention and sensory-motor function, whereas disorganized symptoms correlated with decreased intelligence, attention-span and sensory-motor function. Psychotic symptoms were unrelated to deficits. These data are consistent with hypotheses that these three symptom dimensions have distinct neurobehavioral correlates.

Original languageEnglish (US)
Pages (from-to)99-111
Number of pages13
JournalSchizophrenia Research
Volume31
Issue number2-3
DOIs
StatePublished - May 25 1998
Externally publishedYes

Bibliographical note

Funding Information:
This study was supportedb y a researchg rant i¥om the Board of Regents of Ohio to H.A. Nasrallah,M .D. The authorst hankA. Harkness, E. Newman, R. Nicholson and R.T. Hogan for commentso n a previousd raft of the manuscript.

Keywords

  • Disorganized
  • Negative symptoms
  • Neuropsychological assessment
  • Psychotic

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