Neuroprotective role of IL-4 against activated microglia

Chun C. Chao, Thomas W Molitor, Shuxian Hu

Research output: Contribution to journalArticlepeer-review

200 Scopus citations

Abstract

Microglia have been proposed to play a pathogenetic role in immunologically mediated neurodegenerative diseases. In our study, using microglial/neuronal cell cocultures primed with IFN-γ, we found that both LPS and TNF-α triggered neuronal cell injury (impairment of γ-aminobutyric acid uptake and neuronal loss) via a nitric oxide mechanism. Pretreatment of cell cocultures with IL-4, an immunosuppressive cytokine, prevented, in a dose-dependent manner, neuronal cell injury induced by activated microglia. The mechanism by which IL-4 exerts its neuroprotective effect was found to involve the inhibition of IFN-γ priming of microglia with a subsequent decrease in the production of TNF-α and nitric oxide.

Original languageEnglish (US)
Pages (from-to)1473-1481
Number of pages9
JournalJournal of Immunology
Volume151
Issue number3
StatePublished - 1993

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