Neuropeptide chronomics in clinically healthy young adults: Circaoctohoran and circadian patterns

Alex Löckinger, Dieter Köberle, Paul St. König, Alois Saria, Manfred Herold, Germaine G Cornelissen-Guillaume, Franz Halberg

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Endothelin-1 (ET-1) undergoes an about 8-h (circaoctohoran) rather than a circadian variation in clinical health. Herein, 24 h plasma concentrations of vasoactive intestinal peptide (VIP), substance P (SP), neuropeptide Y (NpY), and cortisol used as reference, were obtained from 20 healthy young adults starting at 07:00 or 19:00 h. Like ET-1, SP and NpY undergo a circaoctohoran variation, whereas VIP is circadian rhythmic, peaking during the night, some 8 h prior to the circadian acrophase of cortisol. Maps of circadian and extra-circadian patterns may serve for screening, diagnosis and a better understanding of mechanisms underlying the etiology of various diseases.

Original languageEnglish (US)
Pages (from-to)533-542
Number of pages10
Issue number4
StatePublished - Apr 2004

Bibliographical note

Funding Information:
We gratefully thank Miss Gabriele Schönhuber for her technical assistance in performing the radioimmunoassays. This study was supported by U.S. National Institutes of Health (GM-13981) (FH) and Dr. h.c. Dr. h.c. Earl Bakken Fund (GC, FH).


  • Circadian
  • Circaoctohoran
  • Cortisol
  • Endothelin-1
  • Neuropeptide Y (NpY)
  • Plasma concentrations
  • Substance P (SP)
  • Vasoactive intestinal peptide (VIP)


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