Abstract
Endothelin-1 (ET-1) undergoes an about 8-h (circaoctohoran) rather than a circadian variation in clinical health. Herein, 24 h plasma concentrations of vasoactive intestinal peptide (VIP), substance P (SP), neuropeptide Y (NpY), and cortisol used as reference, were obtained from 20 healthy young adults starting at 07:00 or 19:00 h. Like ET-1, SP and NpY undergo a circaoctohoran variation, whereas VIP is circadian rhythmic, peaking during the night, some 8 h prior to the circadian acrophase of cortisol. Maps of circadian and extra-circadian patterns may serve for screening, diagnosis and a better understanding of mechanisms underlying the etiology of various diseases.
Original language | English (US) |
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Pages (from-to) | 533-542 |
Number of pages | 10 |
Journal | Peptides |
Volume | 25 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2004 |
Bibliographical note
Funding Information:We gratefully thank Miss Gabriele Schönhuber for her technical assistance in performing the radioimmunoassays. This study was supported by U.S. National Institutes of Health (GM-13981) (FH) and Dr. h.c. Dr. h.c. Earl Bakken Fund (GC, FH).
Keywords
- Circadian
- Circaoctohoran
- Cortisol
- Endothelin-1
- Neuropeptide Y (NpY)
- Plasma concentrations
- Substance P (SP)
- Vasoactive intestinal peptide (VIP)