Neuropathy and mortality in diabetes: Influence of pancreas transplantation

Xavier Navarro, William R. Kennedy, Dorothee Aeppli, David E R Sutherland

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

We collected information on patient status and cause of death for 545 insulindependent diabetic subjects who had cardiorespiratory reflex and nerve conduction tests performed to determine if presence and severity of autonomic and somatic neuropathy is associated with mortality and if a functioning pancreas transplantation (PTx) influences mortality. Follow-up was 12-138 months. Abnormal cardiorespiratory reflexes were present in 417 patients and there was abnormal nerve conduction in 392 patients. Mortality rates for patients with abnormal tests were higher (P < 0.0001) than for patients with normal tests. A total neuropathy score that included cardiorespiratory and nerve conduction test scores predicted survival better than separate scores. Patients with moderate neuropathy, but not those with severe neuropathy, who retained a functioning PTx, had longer survival times than patients whose PTx failed in the first 3 months. Considering only patients transplanted after 1985, those with moderate neuropathy who retained a functioning PTx had even longer survival times than nontransplanted patients.

Original languageEnglish (US)
Pages (from-to)1009-1016
Number of pages8
JournalMuscle and Nerve
Volume19
Issue number8
DOIs
StatePublished - Aug 1996

Keywords

  • autonomic neuropathy
  • cardiorespiratory reflex
  • diabetes
  • nerve conduction
  • survival

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