Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

W. Robert Bell; Yang An; Yusuke Kageyama; Collin English; Gay L. Rudow; Olga Pletnikova; Madhav Thambisetty; Richard O'Brien; Abhay R. Moghekar; Marilyn S. Albert; Peter V. Rabins; Susan M. Resnick; Juan C. Troncoso

doi:10.1016/j.jalz.2018.07.215

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

W. Robert Bell, Yang An, Yusuke Kageyama, Collin English, Gay L. Rudow, Olga Pletnikova, Madhav Thambisetty, Richard O'Brien, Abhay R. Moghekar, Marilyn S. Albert, Peter V. Rabins, Susan M. Resnick, Juan C. Troncoso

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Abstract

Introduction: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Methods: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. Results: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P =.0046). Discussion: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

Original language	English (US)
Pages (from-to)	8-16
Number of pages	9
Journal	Alzheimer's and Dementia
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2018.07.215
State	Published - Jan 2019

Bibliographical note

Funding Information:
PVR received nonfinancial/financial support from Hall Family Foundation , S.I. Newhouse Foundation and royalties from Book royalties from The 36-Hour Day, Practical Dementia Care, and The Why of Things. JCT is supported by the BrightFocus Foundation and NIH Grant R21AGO55844 . OP is supported by the BrightFocus Foundation and the S.I. Newhouse Foundation. WRB,is supported by the S. I. Newhouse Foundation .

Funding Information:
PVR received nonfinancial/financial support from Hall Family Foundation, S.I. Newhouse Foundation and royalties from Book royalties from The 36-Hour Day, Practical Dementia Care, and The Why of Things. JCT is supported by the BrightFocus Foundation and NIH Grant R21AGO55844. OP is supported by the BrightFocus Foundation and the S.I. Newhouse Foundation. WRB,is supported by the S. I. Newhouse Foundation.

Funding Information:
This work is supported in part by the Intramural Research Program of the National Institute on Aging , NIH and the Johns Hopkins University Alzheimer's Disease Research Center ( NIA AG05146 ).

Publisher Copyright:
© 2018

Keywords

Aging
Alzheimer disease (AD)
Dementia
Mild Cognitive Impairment (MCI)
Neurofibrillary tangles
Primary Age-Related Tauopathy (PART)
Public Health Planning

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2018.07.215

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542566

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Bell, W. R., An, Y., Kageyama, Y., English, C., Rudow, G. L., Pletnikova, O., Thambisetty, M., O'Brien, R., Moghekar, A. R., Albert, M. S., Rabins, P. V., Resnick, S. M., & Troncoso, J. C. (2019). Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease. Alzheimer's and Dementia, 15(1), 8-16. https://doi.org/10.1016/j.jalz.2018.07.215

Bell, WR, An, Y, Kageyama, Y, English, C, Rudow, GL, Pletnikova, O, Thambisetty, M, O'Brien, R, Moghekar, AR, Albert, MS, Rabins, PV, Resnick, SM & Troncoso, JC 2019, 'Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease', Alzheimer's and Dementia, vol. 15, no. 1, pp. 8-16. https://doi.org/10.1016/j.jalz.2018.07.215

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abstract = "Introduction: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Methods: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. Results: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P =.0046). Discussion: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.",

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note = "Funding Information: PVR received nonfinancial/financial support from Hall Family Foundation , S.I. Newhouse Foundation and royalties from Book royalties from The 36-Hour Day, Practical Dementia Care, and The Why of Things. JCT is supported by the BrightFocus Foundation and NIH Grant R21AGO55844 . OP is supported by the BrightFocus Foundation and the S.I. Newhouse Foundation. WRB,is supported by the S. I. Newhouse Foundation . Funding Information: PVR received nonfinancial/financial support from Hall Family Foundation, S.I. Newhouse Foundation and royalties from Book royalties from The 36-Hour Day, Practical Dementia Care, and The Why of Things. JCT is supported by the BrightFocus Foundation and NIH Grant R21AGO55844. OP is supported by the BrightFocus Foundation and the S.I. Newhouse Foundation. WRB,is supported by the S. I. Newhouse Foundation. Funding Information: This work is supported in part by the Intramural Research Program of the National Institute on Aging , NIH and the Johns Hopkins University Alzheimer's Disease Research Center ( NIA AG05146 ). Publisher Copyright: {\textcopyright} 2018",

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AU - Bell, W. Robert

AU - An, Yang

AU - Kageyama, Yusuke

AU - English, Collin

AU - Rudow, Gay L.

AU - Pletnikova, Olga

AU - Thambisetty, Madhav

AU - O'Brien, Richard

AU - Moghekar, Abhay R.

AU - Albert, Marilyn S.

AU - Rabins, Peter V.

AU - Resnick, Susan M.

AU - Troncoso, Juan C.

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N2 - Introduction: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Methods: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. Results: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P =.0046). Discussion: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

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Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

Abstract

Bibliographical note

Keywords

UN SDGs

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