Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

W. Robert Bell, Yang An, Yusuke Kageyama, Collin English, Gay L. Rudow, Olga Pletnikova, Madhav Thambisetty, Richard O'Brien, Abhay R. Moghekar, Marilyn S. Albert, Peter V. Rabins, Susan M. Resnick, Juan C. Troncoso

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Introduction: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Methods: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. Results: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P =.0046). Discussion: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalAlzheimer's and Dementia
Volume15
Issue number1
DOIs
StatePublished - Jan 2019
Externally publishedYes

Bibliographical note

Funding Information:
PVR received nonfinancial/financial support from Hall Family Foundation , S.I. Newhouse Foundation and royalties from Book royalties from The 36-Hour Day, Practical Dementia Care, and The Why of Things. JCT is supported by the BrightFocus Foundation and NIH Grant R21AGO55844 . OP is supported by the BrightFocus Foundation and the S.I. Newhouse Foundation. WRB,is supported by the S. I. Newhouse Foundation .

Funding Information:
PVR received nonfinancial/financial support from Hall Family Foundation, S.I. Newhouse Foundation and royalties from Book royalties from The 36-Hour Day, Practical Dementia Care, and The Why of Things. JCT is supported by the BrightFocus Foundation and NIH Grant R21AGO55844. OP is supported by the BrightFocus Foundation and the S.I. Newhouse Foundation. WRB,is supported by the S. I. Newhouse Foundation.

Funding Information:
This work is supported in part by the Intramural Research Program of the National Institute on Aging , NIH and the Johns Hopkins University Alzheimer's Disease Research Center ( NIA AG05146 ).

Publisher Copyright:
© 2018

Keywords

  • Aging
  • Alzheimer disease (AD)
  • Dementia
  • Mild Cognitive Impairment (MCI)
  • Neurofibrillary tangles
  • Primary Age-Related Tauopathy (PART)
  • Public Health Planning

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