Neuronal regulation and function of natriuretic peptide receptor C

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The neuromodulatory effect of natriuretic peptides is probably the best example of a whole organ response mediated by natriuretic peptide C receptors (NPR-Cs). Both NPR-C specific agonists and ablation experiments utilizing NPR-C specific antibodies or antisense oligonucleotides demonstrated the essential signaling role of the NPR-C in these neuromodulatory responses. Our most recent studies utilize peptides representing the NPR-C intracellular region to elucidate the specific signaling region of the NPR-C. These studies have identified an inhibitory influence of NPR-C on adrenergic neurotransmission by a calcium-dependent process.

Original languageEnglish (US)
Pages (from-to)1060-1067
Number of pages8
JournalPeptides
Volume26
Issue number6 SPEC. ISS.
DOIs
StatePublished - Jun 2005

Keywords

  • Adrenergic neurotransmission
  • Calcium
  • Natriuretic peptide receptor C

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